Paul Swift from BikeFit sent out an infographic showing proper wrist alignment – their example is for a mountain bike, but the concept is identical no matter what you're riding. If you've been to WSSC, BikeFit is the company who provides the very popular bicycle shoe cleat alignment / adjustment service.

Complaints about hand numbness are typically the result of riding with hyper-extended wrists. We've explored the need for proper hand position in detail here at ICI/PRO in these posts:
Correcting Student’s Form — Proper Hand Position
More on preventing carpal tunnel / hand numbness in your students
5 Tips that will help you (and your hands) feel more comfortable on your bike
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